Frontotemporal Dementia P301L Mutation Potentiates but Is Not Sufficient to Cause the Formation of Cytotoxic Fibrils of Tau

The P301L mutation in tau protein is a prevalent pathogenic mutation associated with neurodegenerative frontotemporal dementia, FTD. The mechanism by which P301L triggers or facilitates neurodegeneration at the molecular level remains unclear. In this work, we examined the effect of the P301L mutati...

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Detalles Bibliográficos
Autores principales: Wang, Kuang-Wei, Zhang, Gary, Kuo, Min-Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573866/
https://www.ncbi.nlm.nih.gov/pubmed/37834443
http://dx.doi.org/10.3390/ijms241914996

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573866/
https://www.ncbi.nlm.nih.gov/pubmed/37834443
http://dx.doi.org/10.3390/ijms241914996

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