β-Lactam TRPM8 Antagonists Derived from Phe-Phenylalaninol Conjugates: Structure–Activity Relationships and Antiallodynic Activity

The protein transient receptor potential melastatin type 8 (TRPM8), a non-selective, calcium (Ca(2+))-permeable ion channel is implicated in several pathological conditions, including neuropathic pain states. In our previous research endeavors, we have identified β-lactam derivatives with high hydro...

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Detalles Bibliográficos
Autores principales: Martín-Escura, Cristina, Bonache, M. Ángeles, Medina, Jessy A., Medina-Peris, Alicia, De Andrés-López, Jorge, González-Rodríguez, Sara, Kerselaers, Sara, Fernández-Ballester, Gregorio, Voets, Thomas, Ferrer-Montiel, Antonio, Fernández-Carvajal, Asia, González-Muñiz, Rosario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573892/
https://www.ncbi.nlm.nih.gov/pubmed/37834342
http://dx.doi.org/10.3390/ijms241914894

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573892/
https://www.ncbi.nlm.nih.gov/pubmed/37834342
http://dx.doi.org/10.3390/ijms241914894

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