Cargando…

Aggregation, Transmission, and Toxicity of the Microtubule-Associated Protein Tau: A Complex Comprehension

The microtubule-associated protein tau is an intrinsically disordered protein containing a few short and transient secondary structures. Tau physiologically associates with microtubules (MTs) for its stabilization and detaches from MTs to regulate its dynamics. Under pathological conditions, tau is...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hu, Jiaxin, Sha, Wenchi, Yuan, Shuangshuang, Wu, Jiarui, Huang, Yunpeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573976/ https://www.ncbi.nlm.nih.gov/pubmed/37834471 http://dx.doi.org/10.3390/ijms241915023

Ejemplares similares

Aggregation of Microtubule Binding Repeats of Tau Protein is Promoted by Cu(2+)
por: Ahmadi, Soha, et al.
Publicado: (2019)

Suppressing Tau Aggregation and Toxicity by an Anti-Aggregant Tau Fragment
por: Pir, Ghulam Jeelani, et al.
Publicado: (2018)

Motifs in the tau protein that control binding to microtubules and aggregation determine pathological effects
por: Lathuilière, Aurélien, et al.
Publicado: (2017)

Disulfide bond formation in microtubule-associated tau protein promotes tau accumulation and toxicity in vivo
por: Saito, Taro, et al.
Publicado: (2021)

Tau Lysine Pseudomethylation Regulates Microtubule Binding and Enhances Prion-like Tau Aggregation
por: Xia, Yuxing, et al.
Publicado: (2023)

Tau antibody 77G7 targeting microtubule binding domain suppresses proteopathic tau to seed tau aggregation
por: Li, Longfei, et al.
Publicado: (2022)

Tau Phosphorylation, Aggregation, and Cell Toxicity
por: Avila, J., et al.
Publicado: (2006)

Are Tau Aggregates Toxic or Protective in Tauopathies?
por: Cowan, Catherine M., et al.
Publicado: (2013)

Toxic tau: structural origins of tau aggregation in Alzheimer's disease
por: Mamun, Abdullah Al, et al.
Publicado: (2020)

The Fate of Tau Aggregates Between Clearance and Transmission
por: Seitkazina, Assel, et al.
Publicado: (2022)

Microtubule-binding core of the tau protein
por: El Mammeri, Nadia, et al.
Publicado: (2022)

Identification of key amino acids responsible for the distinct aggregation properties of microtubule‐associated protein 2 and tau
por: Xie, Ce, et al.
Publicado: (2015)

Pseudo-acetylation of multiple sites on human Tau proteins alters Tau phosphorylation and microtubule binding, and ameliorates amyloid beta toxicity
por: Gorsky, Marianna Karina, et al.
Publicado: (2017)

Zinc Binding Directly Regulates Tau Toxicity Independent of Tau Hyperphosphorylation
por: Huang, Yunpeng, et al.
Publicado: (2014)

Tau K321/K353 pseudoacetylation within KXGS motifs regulates tau–microtubule interactions and inhibits aggregation
por: Xia, Yuxing, et al.
Publicado: (2021)

The microtubule-associated protein tau is phosphorylated by Syk
por: Lebouvier, Thibaud, et al.
Publicado: (2008)

Dynamical decoration of stabilized-microtubules by Tau-proteins
por: Hervy, Jordan, et al.
Publicado: (2019)

Doxycycline Interferes With Tau Aggregation and Reduces Its Neuronal Toxicity
por: Medina, Luciana, et al.
Publicado: (2021)

Phosphorylation of the overlooked tyrosine 310 regulates the structure, aggregation, and microtubule- and lipid-binding properties of Tau
por: Ait-Bouziad, Nadine, et al.
Publicado: (2020)

Baicalein inhibits heparin-induced Tau aggregation by initializing non-toxic Tau oligomer formation
por: Sonawane, Shweta Kishor, et al.
Publicado: (2021)

Tau proteins: the molecular structure and mode of binding on microtubules
Publicado: (1988)

The MAP2/Tau family of microtubule-associated proteins
por: Dehmelt, Leif, et al.
Publicado: (2005)

An evolutionary roadmap to the microtubule-associated protein MAP Tau
por: Sündermann, Frederik, et al.
Publicado: (2016)

Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau
por: Cabrales Fontela, Yunior, et al.
Publicado: (2017)

Tau binding protein CAPON induces tau aggregation and neurodegeneration
por: Hashimoto, Shoko, et al.
Publicado: (2019)

Tau Enhances α-Synuclein Aggregation and Toxicity in Cellular Models of Synucleinopathy
por: Badiola, Nahuai, et al.
Publicado: (2011)

A Structural Ensemble of a Tau-Microtubule Complex Reveals Regulatory Tau Phosphorylation and Acetylation Mechanisms
por: Brotzakis, Z. Faidon, et al.
Publicado: (2021)

Microtubules Gate Tau Condensation to Spatially Regulate Microtubule Functions
por: Tan, Ruensern, et al.
Publicado: (2019)

Immunodetection of Tau microtubule-associated protein in human sperm and testis
por: Sigala, Julien, et al.
Publicado: (2014)

Atypical, non-standard functions of the microtubule associated Tau protein
por: Sotiropoulos, Ioannis, et al.
Publicado: (2017)

The organization of microtubules and Tau in oligodendrocytes: Tau pathology in damaged oligodendrocytes
por: Torii, Tomohiro, et al.
Publicado: (2022)

Tau mutation S356T in the three repeat isoform leads to microtubule dysfunction and promotes prion-like seeded aggregation
por: Xia, Yuxing, et al.
Publicado: (2023)

Propagation of Tau aggregates
por: Goedert, Michel, et al.
Publicado: (2017)

Tau protein liquid–liquid phase separation can initiate tau aggregation
por: Wegmann, Susanne, et al.
Publicado: (2018)

Author Correction: Tau binding protein CAPON induces tau aggregation and neurodegeneration
por: Hashimoto, Shoko, et al.
Publicado: (2019)

RNA editing of microtubule-associated protein tau circular RNAs promotes their translation and tau tangle formation
por: Welden, Justin Ralph, et al.
Publicado: (2022)

Microtubule-associated protein tau is essential for long-term depression in the hippocampus
por: Kimura, Tetsuya, et al.
Publicado: (2014)

The Microtubule-Associated Protein Tau and Its Relevance for Pancreatic Beta Cells
por: Maj, Magdalena, et al.
Publicado: (2016)

The regulatory effect of Tau protein on polymerization of MCF7 microtubules in vitro
por: Feizabadi, Mitra Shojania, et al.
Publicado: (2019)

Role of Tau as a Microtubule-Associated Protein: Structural and Functional Aspects
por: Barbier, Pascale, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_1bmfe1aq8ijd7gjqiillk8jp68