Cargando…

Sleeping Beauty Transposon Insertions into Nucleolar DNA by an Engineered Transposase Localized in the Nucleolus

Transposons are nature’s gene delivery vehicles that can be harnessed for experimental and therapeutic purposes. The Sleeping Beauty (SB) transposon shows efficient transposition and long-term transgene expression in human cells, and is currently under clinical development for gene therapy. SB trans...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kovač, Adrian, Miskey, Csaba, Ivics, Zoltán
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573994/ https://www.ncbi.nlm.nih.gov/pubmed/37834425 http://dx.doi.org/10.3390/ijms241914978

Ejemplares similares

Engineered Sleeping Beauty transposase redirects transposon integration away from genes
por: Miskey, Csaba, et al.
Publicado: (2022)

A highly soluble Sleeping Beauty transposase improves control of gene insertion
por: Querques, Irma, et al.
Publicado: (2019)

Integration Profile and Safety of an Adenovirus Hybrid-Vector Utilizing Hyperactive Sleeping Beauty Transposase for Somatic Integration
por: Zhang, Wenli, et al.
Publicado: (2013)

Correction: Integration Profile and Safety of an Adenovirus Hybrid-Vector Utilizing Hyperactive Sleeping Beauty Transposase for Somatic Integration
por: Zhang, Wenli, et al.
Publicado: (2020)

RNA-guided retargeting of Sleeping Beauty transposition in human cells
por: Kovač, Adrian, et al.
Publicado: (2020)

Sleeping Beauty transposase structure allows rational design of hyperactive variants for genetic engineering
por: Voigt, Franka, et al.
Publicado: (2016)

Retargeting transposon insertions by the adeno-associated virus Rep protein
por: Ammar, Ismahen, et al.
Publicado: (2012)

Molecular and Functional Characterization of BDNF-Overexpressing Human Retinal Pigment Epithelial Cells Established by Sleeping Beauty Transposon-Mediated Gene Transfer
por: Mattern, Larissa, et al.
Publicado: (2022)

Enhanced Biosafety of the Sleeping Beauty Transposon System by Using mRNA as Source of Transposase to Efficiently and Stably Transfect Retinal Pigment Epithelial Cells
por: Harmening, Nina, et al.
Publicado: (2023)

A single amino acid switch converts the Sleeping Beauty transposase into an efficient unidirectional excisionase with utility in stem cell reprogramming
por: Kesselring, Lisa, et al.
Publicado: (2020)

Evolution-guided evaluation of the inverted terminal repeats of the synthetic transposon Sleeping Beauty
por: Scheuermann, Barbara, et al.
Publicado: (2019)

The Folding of the Specific DNA Recognition Subdomain of the Sleeping Beauty Transposase Is Temperature-Dependent and Is Required for Its Binding to the Transposon DNA
por: Leighton, Gage O., et al.
Publicado: (2014)

Genomic Analysis of Sleeping Beauty Transposon Integration in Human Somatic Cells
por: Turchiano, Giandomenico, et al.
Publicado: (2014)

Contemporary Transposon Tools: A Review and Guide through Mechanisms and Applications of Sleeping Beauty, piggyBac and Tol2 for Genome Engineering
por: Sandoval-Villegas, Nicolás, et al.
Publicado: (2021)

Suicidal Autointegration of Sleeping Beauty and piggyBac Transposons in Eukaryotic Cells
por: Wang, Yongming, et al.
Publicado: (2014)

Sleeping Beauty transposon-based system for cellular reprogramming and targeted gene insertion in induced pluripotent stem cells
por: Grabundzija, Ivana, et al.
Publicado: (2013)

Preclinical Evaluation of a Cell-Based Gene Therapy Using the Sleeping Beauty Transposon System in Choroidal Neovascularization
por: Hernandez, Maria, et al.
Publicado: (2019)

Correction: Genomic Analysis of Sleeping Beauty Transposon Integration in Human Somatic Cells
por: Turchiano, Giandomenico, et al.
Publicado: (2020)

Efficient Non-viral Gene Delivery into Human Hematopoietic Stem Cells by Minicircle Sleeping Beauty Transposon Vectors
por: Holstein, Marta, et al.
Publicado: (2018)

Correction: Suicidal Autointegration of Sleeping Beauty and piggyBac Transposons in Eukaryotic Cells
por: Wang, Yongming, et al.
Publicado: (2019)

Reliable transgene-independent method for determining Sleeping Beauty transposon copy numbers
por: Kolacsek, Orsolya, et al.
Publicado: (2011)

Genome-wide mapping of binding sites of the transposase-derived SETMAR protein in the human genome
por: Miskei, Márton, et al.
Publicado: (2021)

Correction: Reliable transgene-independent method for determining sleeping beauty transposon copy numbers
por: Kolacsek, Orsolya, et al.
Publicado: (2013)

Transcriptionally regulated and nontoxic delivery of the hyperactive Sleeping Beauty Transposase
por: Cocchiarella, Fabienne, et al.
Publicado: (2016)

Transgene Expression and Transposition Efficiency of Two-Component Sleeping Beauty Transposon Vector Systems Utilizing Plasmid or mRNA Encoding the Transposase
por: Tschorn, Natalie, et al.
Publicado: (2022)

Genome-wide Profiling Reveals Remarkable Parallels Between Insertion Site Selection Properties of the MLV Retrovirus and the piggyBac Transposon in Primary Human CD4(+) T Cells
por: Gogol-Döring, Andreas, et al.
Publicado: (2016)

The expanding universe of transposon technologies for gene and cell engineering
por: Ivics, Zoltán, et al.
Publicado: (2010)

Insertional mutagenesis using the Sleeping Beauty transposon system identifies drivers of erythroleukemia in mice
por: Loeb, Keith R., et al.
Publicado: (2019)

A hyperactive sleeping beauty transposase enhances transgenesis in zebrafish embryos
por: Newman, Morgan, et al.
Publicado: (2010)

Transcriptionally promiscuous “blurry” promoters in Tc1/mariner transposons allow transcription in distantly related genomes
por: Palazzo, Antonio, et al.
Publicado: (2019)

Engineered Sleeping Beauty Transposon as Efficient System to Optimize Chimp Adenoviral Production
por: Baldassarri, Samantha, et al.
Publicado: (2022)

Intruder (DD38E), a recently evolved sibling family of DD34E/Tc1 transposons in animals
por: Gao, Bo, et al.
Publicado: (2020)

Passer, a highly active transposon from a fish genome, as a potential new robust genetic manipulation tool
por: Wang, Saisai, et al.
Publicado: (2023)

Jumping Ahead with Sleeping Beauty: Mechanistic Insights into Cut-and-Paste Transposition
por: Ochmann, Matthias T., et al.
Publicado: (2021)

Regulation of DNA transposition by CpG methylation and chromatin structure in human cells
por: Jursch, Tobias, et al.
Publicado: (2013)

Engineering of PEDF-Expressing Primary Pigment Epithelial Cells by the SB Transposon System Delivered by pFAR4 Plasmids
por: Thumann, Gabriele, et al.
Publicado: (2017)

Transposons for cancer gene discovery: Sleeping Beauty and beyond
por: Collier, Lara S, et al.
Publicado: (2007)

Enhancer trapping in zebrafish using the Sleeping Beauty transposon
por: Balciunas, Darius, et al.
Publicado: (2004)

Restoration of dystrophin expression using the Sleeping Beauty transposon
por: Muses, Sofia, et al.
Publicado: (2012)

Remobilization of Sleeping Beauty transposons in the germline of Xenopus tropicalis
por: Yergeau, Donald A, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_2pdf5nkumdhjn1v73fq7das6ad