Revisiting Supersaturation of a Biopharmaceutical Classification System IIB Drug: Evaluation via a Multi-Cup Dissolution Approach and Molecular Dynamic Simulation

As a subclass of the biopharmaceutical classification system (BCS) class II, basic drugs (BCS IIB) exhibit pH-dependent solubility and tend to generate supersaturation in the gastrointestinal tract, leading to less qualified in vitro–in vivo correlation (IVIVC). This study aims to develop a physiolo...

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Detalles Bibliográficos
Autores principales: Gan, Yanxiong, Xu, Yaxin, Zhang, Xue, Hu, Huiling, Xiao, Wenke, Yu, Zheng, Sun, Tao, Zhang, Jinming, Wen, Chuanbiao, Zheng, Shichao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10574532/
https://www.ncbi.nlm.nih.gov/pubmed/37836805
http://dx.doi.org/10.3390/molecules28196962

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10574532/
https://www.ncbi.nlm.nih.gov/pubmed/37836805
http://dx.doi.org/10.3390/molecules28196962

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