The Inhibitory Effect of Magnolol on the Human TWIK1 Channel Is Related to G229 and T225 Sites

TWIK1 (K2P1.1/KCNK1) belongs to the potassium channels of the two-pore domain. Its current is very small and difficult to measure. In this work, we used a 100 mM NH(4)(+) extracellular solution to increase TWIK1 current in its stable cell line expressed in HEK293. Then, the inhibition of magnolol on...

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Detalles Bibliográficos
Autores principales: Wang, Jintao, Liu, Huan, Sun, Zhuolin, Zou, Xinyi, Zhang, Zixuan, Wei, Xiaofeng, Pan, Lanying, Stalin, Antony, Zhao, Wei, Chen, Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10574557/
https://www.ncbi.nlm.nih.gov/pubmed/37836658
http://dx.doi.org/10.3390/molecules28196815

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10574557/
https://www.ncbi.nlm.nih.gov/pubmed/37836658
http://dx.doi.org/10.3390/molecules28196815

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