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The Inhibitory Effect of Magnolol on the Human TWIK1 Channel Is Related to G229 and T225 Sites

TWIK1 (K2P1.1/KCNK1) belongs to the potassium channels of the two-pore domain. Its current is very small and difficult to measure. In this work, we used a 100 mM NH(4)(+) extracellular solution to increase TWIK1 current in its stable cell line expressed in HEK293. Then, the inhibition of magnolol on...

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Detalles Bibliográficos
Autores principales:	Wang, Jintao, Liu, Huan, Sun, Zhuolin, Zou, Xinyi, Zhang, Zixuan, Wei, Xiaofeng, Pan, Lanying, Stalin, Antony, Zhao, Wei, Chen, Yuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10574557/ https://www.ncbi.nlm.nih.gov/pubmed/37836658 http://dx.doi.org/10.3390/molecules28196815

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