Synthesis and Characterization of Edaravone Analogues as Remyelinating Agents and Putative Mechanistic Probes

Edaravone (EDA), an antioxidant drug approved for the treatment of ischemic stroke and amyotrophic lateral sclerosis, was recently proposed as a remyelinating candidate for the treatment of multiple sclerosis. Here, we synthesized twelve EDA analogues 2b–4c showing three substitution patterns A–C, s...

Descripción completa

Detalles Bibliográficos
Autores principales: Colombo, Eleonora, Olla, Stefania, Minnelli, Cristina, Formato, Alessia, Veroni, Caterina, Corbisiero, Silvia, Pericolo, Mattia, Siguri, Chiara, Mobbili, Giovanna, Agresti, Cristina, Seneci, Pierfausto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10574562/
https://www.ncbi.nlm.nih.gov/pubmed/37836771
http://dx.doi.org/10.3390/molecules28196928

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10574562/
https://www.ncbi.nlm.nih.gov/pubmed/37836771
http://dx.doi.org/10.3390/molecules28196928

Ejemplares similares