Benzophenanthridine Alkaloid Chelerythrine Elicits Necroptosis of Gastric Cancer Cells via Selective Conjugation at the Redox Hyperreactive C-Terminal Sec(498) Residue of Cytosolic Selenoprotein Thioredoxin Reductase

Targeting thioredoxin reductase (TXNRD) with low-weight molecules is emerging as a high-efficacy anti-cancer strategy in chemotherapy. Sanguinarine has been reported to inhibit the activity of TXNRD1, indicating that benzophenanthridine alkaloid is a fascinating chemical entity in the field of TXNRD...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Minghui, Sun, Shibo, Meng, Yao, Wang, Ling, Liu, Haowen, Shi, Wuyang, Zhang, Qiuyu, Xu, Weiping, Sun, Bingbing, Xu, Jianqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10574601/
https://www.ncbi.nlm.nih.gov/pubmed/37836684
http://dx.doi.org/10.3390/molecules28196842

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10574601/
https://www.ncbi.nlm.nih.gov/pubmed/37836684
http://dx.doi.org/10.3390/molecules28196842

Ejemplares similares