Optimization of Bromocriptine-Mesylate-Loaded Polycaprolactone Nanoparticles Coated with Chitosan for Nose-to-Brain Delivery: In Vitro and In Vivo Studies

Bromocriptine mesylate (BM), primarily ergocryptine, is a dopamine agonist derived from ergot alkaloids. This study aimed to formulate chitosan (CS)-coated poly ε-caprolactone nanoparticles (PCL NPs) loaded with BM for direct targeting to the brain via the nasal route. PCL NPs were optimized using r...

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Detalles Bibliográficos
Autores principales: Badran, Mohamed M., Alanazi, Abdulrahman E., Ibrahim, Mohamed Abbas, Alshora, Doaa Hasan, Taha, Ehab, H. Alomrani, Abdullah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10574927/
https://www.ncbi.nlm.nih.gov/pubmed/37835942
http://dx.doi.org/10.3390/polym15193890

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10574927/
https://www.ncbi.nlm.nih.gov/pubmed/37835942
http://dx.doi.org/10.3390/polym15193890

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