Coinhibition of topoisomerase 1 and BRD4-mediated pause release selectively kills pancreatic cancer via readthrough transcription

Pancreatic carcinoma lacks effective therapeutic strategies resulting in poor prognosis. Transcriptional dysregulation due to alterations in KRAS and MYC affects initiation, development, and survival of this tumor type. Using patient-derived xenografts of KRAS- and MYC-driven pancreatic carcinoma, w...

Descripción completa

Detalles Bibliográficos
Autores principales: Cameron, Donald P., Grosser, Jan, Ladigan, Swetlana, Kuzin, Vladislav, Iliopoulou, Evanthia, Wiegard, Anika, Benredjem, Hajar, Jackson, Kathryn, Liffers, Sven T., Lueong, Smiths, Cheung, Phyllis F., Vangala, Deepak, Pohl, Michael, Viebahn, Richard, Teschendorf, Christian, Wolters, Heiner, Usta, Selami, Geng, Keyi, Kutter, Claudia, Arsenian-Henriksson, Marie, Siveke, Jens T., Tannapfel, Andrea, Schmiegel, Wolff, Hahn, Stephan A., Baranello, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575591/
https://www.ncbi.nlm.nih.gov/pubmed/37831776
http://dx.doi.org/10.1126/sciadv.adg5109

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575591/
https://www.ncbi.nlm.nih.gov/pubmed/37831776
http://dx.doi.org/10.1126/sciadv.adg5109

Ejemplares similares