Repression of rRNA gene transcription by endothelial SPEN deficiency normalizes tumor vasculature via nucleolar stress

Human cancers induce a chaotic, dysfunctional vasculature that promotes tumor growth and blunts most current therapies; however, the mechanisms underlying the induction of a dysfunctional vasculature have been unclear. Here, we show that split end (SPEN), a transcription repressor, coordinates rRNA...

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Detalles Bibliográficos
Autores principales: Yang, Zi-Yan, Yan, Xian-Chun, Zhang, Jia-Yu-Lin, Liang, Liang, Gao, Chun-Chen, Zhang, Pei-Ran, Liu, Yuan, Sun, Jia-Xing, Ruan, Bai, Duan, Juan-Li, Wang, Ruo-Nan, Feng, Xing-Xing, Che, Bo, Xiao, Tian, Han, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575731/
https://www.ncbi.nlm.nih.gov/pubmed/37607001
http://dx.doi.org/10.1172/JCI159860

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575731/
https://www.ncbi.nlm.nih.gov/pubmed/37607001
http://dx.doi.org/10.1172/JCI159860

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