Ex vivo drug sensitivity screening predicts response to temozolomide in glioblastoma patients and identifies candidate biomarkers

BACKGROUND: Patient-derived glioma stem-like cells (GSCs) have become the gold-standard in neuro-oncological research; however, it remains to be established whether loss of in situ microenvironment affects the clinically-predictive value of this model. We implemented a GSC monolayer system to invest...

Descripción completa

Detalles Bibliográficos
Autores principales: Ntafoulis, Ioannis, Kleijn, Anne, Ju, Jie, Jimenez-Cowell, Kevin, Fabro, Federica, Klein, Michelle, Chi Yen, Romain Tching, Balvers, Rutger K., Li, Yunlei, Stubbs, Andrew P., Kers, Trisha V., Kros, Johan M., Lawler, Sean E., Beerepoot, Laurens V., Kremer, Andreas, Idbaih, Ahmed, Verreault, Maite, Byrne, Annette T., O’Farrell, Alice C., Connor, Kate, Biswas, Archita, Salvucci, Manuela, Prehn, Jochen H. M., Lambrechts, Diether, Dilcan, Gonca, Lodi, Francesca, Arijs, Ingrid, van den Bent, Martin J., Dirven, Clemens M. F., Leenstra, Sieger, Lamfers, Martine L. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575865/
https://www.ncbi.nlm.nih.gov/pubmed/37620410
http://dx.doi.org/10.1038/s41416-023-02402-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575865/
https://www.ncbi.nlm.nih.gov/pubmed/37620410
http://dx.doi.org/10.1038/s41416-023-02402-y

Ejemplares similares