Structural insights into the allosteric inhibition of P2X4 receptors

P2X receptors are ATP-activated cation channels, and the P2X4 subtype plays important roles in the immune system and the central nervous system, particularly in neuropathic pain. Therefore, P2X4 receptors are of increasing interest as potential drug targets. Here, we report the cryo-EM structures of...

Descripción completa

Detalles Bibliográficos
Autores principales: Shen, Cheng, Zhang, Yuqing, Cui, Wenwen, Zhao, Yimeng, Sheng, Danqi, Teng, Xinyu, Shao, Miaoqing, Ichikawa, Muneyoshi, Wang, Jin, Hattori, Motoyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575874/
https://www.ncbi.nlm.nih.gov/pubmed/37833294
http://dx.doi.org/10.1038/s41467-023-42164-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575874/
https://www.ncbi.nlm.nih.gov/pubmed/37833294
http://dx.doi.org/10.1038/s41467-023-42164-y

Ejemplares similares