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Mercaptonicotinic acid activated thiolated chitosan (MNA-TG-chitosan) to enable peptide oral delivery by opening cell tight junctions and enhancing transepithelial transport

Recent advances in peptide delivery and nanotechnology has resulted in emergence of several non-parenteral administration routes that replace subcutaneous injections associated with patient discomfort. Thiolated biopolymers are relatively new materials being explored to enhance mucoadhesivity and pe...

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Detalles Bibliográficos
Autores principales: Pratap-Singh, Anubhav, Guo, Yigong, Baldelli, Alberto, Singh, Anika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575883/
https://www.ncbi.nlm.nih.gov/pubmed/37833426
http://dx.doi.org/10.1038/s41598-023-44178-4