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MEK inhibitors increase the mortality rate in mice with LPS-induced inflammation through IL-12-NO signaling

Lipopolysaccharide (LPS) is an endotoxin that can cause an acute inflammatory response. Nitric oxide (NO) is one of the most important innate immune system components and is synthesized by inducible NOS (iNOS) in macrophages in response to stimulation with LPS. LPS activates the RAS-RAF-mitogen-acti...

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Detalles Bibliográficos
Autores principales: Hashimoto, Ryota, Koide, Hiroshi, Katoh, Youichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575927/
https://www.ncbi.nlm.nih.gov/pubmed/37833247
http://dx.doi.org/10.1038/s41420-023-01674-w