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MEK inhibitors increase the mortality rate in mice with LPS-induced inflammation through IL-12-NO signaling
Lipopolysaccharide (LPS) is an endotoxin that can cause an acute inflammatory response. Nitric oxide (NO) is one of the most important innate immune system components and is synthesized by inducible NOS (iNOS) in macrophages in response to stimulation with LPS. LPS activates the RAS-RAF-mitogen-acti...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575927/ https://www.ncbi.nlm.nih.gov/pubmed/37833247 http://dx.doi.org/10.1038/s41420-023-01674-w |