DNA damage induced by CDK4 and CDK6 blockade triggers anti-tumor immune responses through cGAS-STING pathway

CDK4/6 are important regulators of cell cycle and their inhibitors have been approved as anti-cancer drugs. Here, we report a STING-dependent anti-tumor immune mechanism responsible for tumor suppression by CDK4/6 blockade. Clinical datasets show that in human tissues, CDK4 and CDK6 are over-express...

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Detalles Bibliográficos
Autores principales: Fan, Huimin, Liu, Wancheng, Zeng, Yanqiong, Zhou, Ying, Gao, Meiling, Yang, Liping, Liu, Hao, Shi, Yueyue, Li, Lili, Ma, Jiayuan, Ruan, Jiayin, Cao, Ruyun, Jin, Xiaoxia, Chen, Jian, Cheng, Genhong, Yang, Heng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575937/
https://www.ncbi.nlm.nih.gov/pubmed/37833461
http://dx.doi.org/10.1038/s42003-023-05412-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575937/
https://www.ncbi.nlm.nih.gov/pubmed/37833461
http://dx.doi.org/10.1038/s42003-023-05412-x

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