Lipid nanoparticles with PEG-variant surface modifications mediate genome editing in the mouse retina

Ocular delivery of lipid nanoparticle (LNPs) packaged mRNA can enable efficient gene delivery and editing. We generated LNP variants through the inclusion of positively charged-amine-modified polyethylene glycol (PEG)-lipids (LNPa), negatively charged-carboxyl-(LNPz) and carboxy-ester (LNPx) modifie...

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Detalles Bibliográficos
Autores principales: Gautam, Milan, Jozic, Antony, Su, Grace Li-Na, Herrera-Barrera, Marco, Curtis, Allison, Arrizabalaga, Sebastian, Tschetter, Wayne, Ryals, Renee C., Sahay, Gaurav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575971/
https://www.ncbi.nlm.nih.gov/pubmed/37833442
http://dx.doi.org/10.1038/s41467-023-42189-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575971/
https://www.ncbi.nlm.nih.gov/pubmed/37833442
http://dx.doi.org/10.1038/s41467-023-42189-3

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