USP36 stabilizes nucleolar Snail1 to promote ribosome biogenesis and cancer cell survival upon ribotoxic stress

Tumor growth requires elevated ribosome biogenesis. Targeting ribosomes is an important strategy for cancer therapy. The ribosome inhibitor, homoharringtonine (HHT), is used for the clinical treatment of leukemia, yet it is ineffective for the treatment of solid tumors, the reasons for which remain...

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Detalles Bibliográficos
Autores principales: Qin, Kewei, Yu, Shuhan, Liu, Yang, Guo, Rongtian, Guo, Shiya, Fei, Junjie, Wang, Yuemeng, Jia, Kaiyuan, Xu, Zhiqiang, Chen, Hu, Li, Fengtian, Niu, Mengmeng, Dai, Mu-Shui, Dai, Lunzhi, Cao, Yang, Zhang, Yujun, Xiao, Zhi-Xiong Jim, Yi, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575996/
https://www.ncbi.nlm.nih.gov/pubmed/37833415
http://dx.doi.org/10.1038/s41467-023-42257-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575996/
https://www.ncbi.nlm.nih.gov/pubmed/37833415
http://dx.doi.org/10.1038/s41467-023-42257-8

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