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USP36 stabilizes nucleolar Snail1 to promote ribosome biogenesis and cancer cell survival upon ribotoxic stress
Tumor growth requires elevated ribosome biogenesis. Targeting ribosomes is an important strategy for cancer therapy. The ribosome inhibitor, homoharringtonine (HHT), is used for the clinical treatment of leukemia, yet it is ineffective for the treatment of solid tumors, the reasons for which remain...
Autores principales: | Qin, Kewei, Yu, Shuhan, Liu, Yang, Guo, Rongtian, Guo, Shiya, Fei, Junjie, Wang, Yuemeng, Jia, Kaiyuan, Xu, Zhiqiang, Chen, Hu, Li, Fengtian, Niu, Mengmeng, Dai, Mu-Shui, Dai, Lunzhi, Cao, Yang, Zhang, Yujun, Xiao, Zhi-Xiong Jim, Yi, Yong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575996/ https://www.ncbi.nlm.nih.gov/pubmed/37833415 http://dx.doi.org/10.1038/s41467-023-42257-8 |
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