Loss of Pde1 function acts as an evolutionary gateway to penicillin resistance in Streptococcus pneumoniae

Streptococcus pneumoniae is a major human pathogen and rising resistance to β-lactam antibiotics, such as penicillin, is a significant threat to global public health. Mutations occurring in the penicillin-binding proteins (PBPs) can confer high-level penicillin resistance but other poorly understood...

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Detalles Bibliográficos
Autores principales: Kobras, Carolin M., Monteith, William, Somerville, Sophie, Delaney, James M., Khan, Imran, Brimble, Camilla, Corrigan, Rebecca M., Sheppard, Samuel K., Fenton, Andrew K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10576035/
https://www.ncbi.nlm.nih.gov/pubmed/37796984
http://dx.doi.org/10.1073/pnas.2308029120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10576035/
https://www.ncbi.nlm.nih.gov/pubmed/37796984
http://dx.doi.org/10.1073/pnas.2308029120

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