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Loss of Pde1 function acts as an evolutionary gateway to penicillin resistance in Streptococcus pneumoniae
Streptococcus pneumoniae is a major human pathogen and rising resistance to β-lactam antibiotics, such as penicillin, is a significant threat to global public health. Mutations occurring in the penicillin-binding proteins (PBPs) can confer high-level penicillin resistance but other poorly understood...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10576035/ https://www.ncbi.nlm.nih.gov/pubmed/37796984 http://dx.doi.org/10.1073/pnas.2308029120 |