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Intrinsic structural dynamics dictate enzymatic activity and inhibition
Enzymes are known to sample various conformations, many of which are critical for their biological function. However, structural characterizations of enzymes predominantly focus on the most populated conformation. As a result, single-point mutations often produce structures that are similar or essen...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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National Academy of Sciences
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10576142/ https://www.ncbi.nlm.nih.gov/pubmed/37782780 http://dx.doi.org/10.1073/pnas.2310910120 |