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A Type 1 Diabetes Polygenic Score Is Not Associated With Prevalent Type 2 Diabetes in Large Population Studies

CONTEXT: Both type 1 diabetes (T1D) and type 2 diabetes (T2D) have significant genetic contributions to risk and understanding their overlap can offer clinical insight. OBJECTIVE: We examined whether a T1D polygenic score (PS) was associated with a diagnosis of T2D in the Cohorts for Heart and Aging...

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Detalles Bibliográficos
Autores principales: Srinivasan, Shylaja, Wu, Peitao, Mercader, Josep M, Udler, Miriam S, Porneala, Bianca C, Bartz, Traci M, Floyd, James S, Sitlani, Colleen, Guo, Xiquing, Haessler, Jeffrey, Kooperberg, Charles, Liu, Jun, Ahmad, Shahzad, van Duijn, Cornelia, Liu, Ching-Ti, Goodarzi, Mark O, Florez, Jose C, Meigs, James B, Rotter, Jerome I, Rich, Stephen S, Dupuis, Josée, Leong, Aaron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10576255/
https://www.ncbi.nlm.nih.gov/pubmed/37841955
http://dx.doi.org/10.1210/jendso/bvad123