Axonal Transport of Lysosomes Is Unaffected in Glucocerebrosidase-Inhibited iPSC-Derived Forebrain Neurons

Lysosomes are acidic organelles that traffic throughout neurons delivering catabolic enzymes to distal regions of the cell and maintaining degradative demands. Loss of function mutations in the gene GBA encoding the lysosomal enzyme glucocerebrosidase (GCase) cause the lysosomal storage disorder Gau...

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Detalles Bibliográficos
Autores principales: Keefe, A. J., Gabrych, D. R., Zhu, Y., Vocadlo, D. J., Silverman, M. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2023
Materias:
Research Article: Negative Results
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10576257/
https://www.ncbi.nlm.nih.gov/pubmed/37816595
http://dx.doi.org/10.1523/ENEURO.0079-23.2023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10576257/
https://www.ncbi.nlm.nih.gov/pubmed/37816595
http://dx.doi.org/10.1523/ENEURO.0079-23.2023

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