Cargando…

Axonal Transport of Lysosomes Is Unaffected in Glucocerebrosidase-Inhibited iPSC-Derived Forebrain Neurons

Lysosomes are acidic organelles that traffic throughout neurons delivering catabolic enzymes to distal regions of the cell and maintaining degradative demands. Loss of function mutations in the gene GBA encoding the lysosomal enzyme glucocerebrosidase (GCase) cause the lysosomal storage disorder Gau...

Descripción completa

Detalles Bibliográficos
Autores principales:	Keefe, A. J., Gabrych, D. R., Zhu, Y., Vocadlo, D. J., Silverman, M. A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Society for Neuroscience 2023
Materias:	Research Article: Negative Results
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10576257/ https://www.ncbi.nlm.nih.gov/pubmed/37816595 http://dx.doi.org/10.1523/ENEURO.0079-23.2023

Ejemplares similares

Aging Does Not Affect Axon Initial Segment Structure and Somatic Localization of Tau Protein in Hippocampal Neurons of Fischer 344 Rats
por: Kneynsberg, Andrew, et al.
Publicado: (2017)

Semaphorin3A Signaling Is Dispensable for Motor Axon Reinnervation of the Adult Neuromuscular Junction
por: Shadrach, Jennifer L., et al.
Publicado: (2018)

Inhibition of Poly-ADP-Ribosylation Fails to Increase Axonal Regeneration or Improve Functional Recovery after Adult Mammalian CNS Injury
por: Wang, Xingxing, et al.
Publicado: (2016)

Vibrio vulnificus iron transport mutant has normal pathogenicity in C. elegans
por: Bowles, Adria K, et al.
Publicado: (2019)

GSK3β Impairs KIF1A Transport in a Cellular Model of Alzheimer’s Disease but Does Not Regulate Motor Motility at S402
por: Gan, K.J., et al.
Publicado: (2020)

Deletion of Ripk3 Prevents Motor Neuron Death In Vitro but not In Vivo
por: Dermentzaki, Georgia, et al.
Publicado: (2019)

Metabotropic Glutamate Receptor 2/3 (mGluR2/3) Activation Suppresses TRPV1 Sensitization in Mouse, But Not Human, Sensory Neurons
por: Sheahan, Tayler D., et al.
Publicado: (2018)

Loss of α-Synuclein Does Not Affect Mitochondrial Bioenergetics in Rodent Neurons
por: Pathak, Divya, et al.
Publicado: (2017)

Validity Assessment of 5 Day Repeated Forced-Swim Stress to Model Human Depression in Young-Adult C57BL/6J and BALB/cJ Mice
por: Mul, Joram D., et al.
Publicado: (2016)

DMD-10 is dispensable for the initial development of amphid sensory neurons and their survival in mature C. elegans
por: Nguyen, Irene, et al.
Publicado: (2021)

The Q system for conditional gene expression is leaky and lacks dynamic range in C. elegans neurons
por: Driesschaert, Brecht, et al.
Publicado: (2022)

Development of GABAergic Inputs Is Not Altered in Early Maturation of Adult Born Dentate Granule Neurons in Fragile X Mice
por: Remmers, Christine L., et al.
Publicado: (2018)

No Evidence for Sex Differences in the Electrophysiological Properties and Excitatory Synaptic Input onto Nucleus Accumbens Shell Medium Spiny Neurons123
por: Willett, Jaime A., et al.
Publicado: (2016)

Effects of Exercise on Progranulin Levels and Gliosis in Progranulin-Insufficient Mice1,2,3
por: Arrant, Andrew E., et al.
Publicado: (2015)

Exploring sex differences for acute ischemic stroke clinical, imaging and thrombus characteristics in the INTERRSeCT study
por: Rebchuk, Alexander D, et al.
Publicado: (2023)

FGF-23 Deficiency Impairs Hippocampal-Dependent Cognitive Function
por: Laszczyk, Ann M., et al.
Publicado: (2019)

Glucagon-Like Peptide-1 Receptor Agonist Treatment Does Not Reduce Abuse-Related Effects of Opioid Drugs
por: Bornebusch, Annika Billefeld, et al.
Publicado: (2019)

Certain types of iron oxide nanoparticles are not suited to passively target inflammatory cells that infiltrate the brain in response to stroke
por: Harms, Christoph, et al.
Publicado: (2013)

Caenorhabditis Intervention Testing Program: the tyrosine kinase inhibitor imatinib mesylate does not extend lifespan in nematodes
por: Coleman-Hulbert, Anna L., et al.
Publicado: (2019)

Caenorhabditis Intervention Testing Program: the creatine analog β-guanidinopropionic acid does not extend lifespan in nematodes
por: Coleman-Hulbert, Anna L., et al.
Publicado: (2020)

Caenorhabditis Intervention Testing Program: the herbicide diuron does not robustly extend lifespan in nematodes
por: Osman, Hadley C, et al.
Publicado: (2021)

Sequencing analysis of the spinal bulbar muscular atrophy CAG expansion reveals absence of repeat interruptions()
por: Fratta, Pietro, et al.
Publicado: (2014)

Hypoxia Inducible Factor-1α in Astrocytes and/or Myeloid Cells Is Not Required for the Development of Autoimmune Demyelinating Disease1,2,3
por: Le Moan, Natacha, et al.
Publicado: (2015)

The Polg Mutator Phenotype Does Not Cause Dopaminergic Neurodegeneration in DJ-1-Deficient Mice1,2,3
por: Hauser, David N., et al.
Publicado: (2015)

Preservation of Essential Odor-Guided Behaviors and Odor-Based Reversal Learning after Targeting Adult Brain Serotonin Synthesis
por: Carlson, Kaitlin S., et al.
Publicado: (2016)

Online LI-rTMS during a Visual Learning Task: Differential Impacts on Visual Circuit and Behavioral Plasticity in Adult Ephrin-A2A5(–/–) Mice
por: Poh, Eugenia Z., et al.
Publicado: (2018)

Pharmacological Dopamine Manipulation Does Not Alter Reward-Based Improvements in Memory Retention during a Visuomotor Adaptation Task
por: Quattrocchi, Graziella, et al.
Publicado: (2018)

Evidence against the Detectability of a Hippocampal Place Code Using Functional Magnetic Resonance Imaging
por: Nolan, Christopher R., et al.
Publicado: (2018)

Cyfip1 Haploinsufficiency Does Not Alter GABA(A) Receptor δ-Subunit Expression and Tonic Inhibition in Dentate Gyrus PV(+) Interneurons and Granule Cells
por: Trent, Simon, et al.
Publicado: (2019)

Centrifugal Innervation of the Olfactory Bulb: A Reappraisal
por: in ’t Zandt, Estelle E., et al.
Publicado: (2019)

Effects of Selective Deletion of Tyrosine Hydroxylase from Kisspeptin Cells on Puberty and Reproduction in Male and Female Mice
por: Stephens, Shannon B. Z., et al.
Publicado: (2017)

Loss of nucleosome remodelers CHRAC/ACF does not sensitize early Drosophila embryos to X-rays
por: Scacchetti, Alessandro, et al.
Publicado: (2020)

The cadmium-responsive gene, cdr-6, does not influence Caenorhabditis elegans responses to exogenous zinc
por: Evans, Kathryn S, et al.
Publicado: (2020)

Closed-Loop Acoustic Stimulation Enhances Sleep Oscillations But Not Memory Performance
por: Henin, Simon, et al.
Publicado: (2019)

The GLR-1 phenotypes of the daf-7(e1372) allele are not temperature sensitive
por: McGehee, Annette
Publicado: (2019)

The mir-35-42 binding site in the nhl-2 3’UTR is dispensable for development and fecundity
por: Yang, Bing, et al.
Publicado: (2020)

Resolving a contradiction: full gene deletion of kqt-3 by CRISPR does not lead to pharyngeal pumping defects
por: Bauer, Rosemary, et al.
Publicado: (2019)

Sarm1 is dispensable for mechanosensory-motor transformations in zebrafish
por: Asgharsharghi, Amir, et al.
Publicado: (2021)

Saul-Wilson Syndrome Missense Allele Does Not Show Obvious Golgi Defects in a C. elegans Model
por: Zafra, Isabella, et al.
Publicado: (2021)

Using the Drosophila Transcriptional Reporter of Intracellular Calcium (TRIC) to examine lasting ethanol-induced changes in neuroexcitability
por: Merriman, Kahlan, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_k3lq2mgfovh0vgd5f27jmvd04p