Heterologous overproduction of oviedomycin by refactoring biosynthetic gene cluster and metabolic engineering of host strain Streptomyces coelicolor

BACKGROUND: Oviedomycin is one among several polyketides known for their potential as anticancer agents. The biosynthetic gene cluster (BGC) for oviedomycin is primarily found in Streptomyces antibioticus. However, because this BGC is usually inactive under normal laboratory conditions, it is necess...

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Detalles Bibliográficos
Autores principales: Gu, Boncheol, Kim, Duck Gyun, Kim, Do-Kyung, Kim, Minji, Kim, Hyun Uk, Oh, Min-Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10576301/
https://www.ncbi.nlm.nih.gov/pubmed/37838667
http://dx.doi.org/10.1186/s12934-023-02218-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10576301/
https://www.ncbi.nlm.nih.gov/pubmed/37838667
http://dx.doi.org/10.1186/s12934-023-02218-8

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