Direct regulation of the cardiac ryanodine receptor (RyR2) by O-GlcNAcylation

BACKGROUND: O-GlcNAcylation is the enzymatic addition of a sugar, O-linked β-N-Acetylglucosamine, to the serine and threonine residues of proteins, and is abundant in diabetic conditions. We have previously shown that O-GlcNAcylation can trigger arrhythmias by indirectly increasing pathological Ca(2...

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Detalles Bibliográficos
Autores principales: Okolo, Chidinma A, Khaing, Ei-Phyo, Mereacre, Valeria, Wallace, Rachel S, Munro, Michelle L, Erickson, Jeffrey R, Jones, Peter P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10576323/
https://www.ncbi.nlm.nih.gov/pubmed/37833717
http://dx.doi.org/10.1186/s12933-023-02010-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10576323/
https://www.ncbi.nlm.nih.gov/pubmed/37833717
http://dx.doi.org/10.1186/s12933-023-02010-3

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