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Direct regulation of the cardiac ryanodine receptor (RyR2) by O-GlcNAcylation
BACKGROUND: O-GlcNAcylation is the enzymatic addition of a sugar, O-linked β-N-Acetylglucosamine, to the serine and threonine residues of proteins, and is abundant in diabetic conditions. We have previously shown that O-GlcNAcylation can trigger arrhythmias by indirectly increasing pathological Ca(2...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10576323/ https://www.ncbi.nlm.nih.gov/pubmed/37833717 http://dx.doi.org/10.1186/s12933-023-02010-3 |