The role and impact of alternative polyadenylation and miRNA regulation on the expression of the multidrug resistance-associated protein 1 (MRP-1/ABCC1) in epithelial ovarian cancer

The ATP-binding cassette transporter (ABCC1) is associated with poor survival and chemotherapy drug resistance in high grade serous ovarian cancer (HGSOC). The mechanisms driving ABCC1 expression are poorly understood. Alternative polyadenylation (APA) can give rise to ABCC1 mRNAs which differ only...

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Detalles Bibliográficos
Autores principales: Marjamaa, Audrey, Gibbs, Bettine, Kotrba, Chloe, Masamha, Chioniso Patience
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10576765/
https://www.ncbi.nlm.nih.gov/pubmed/37838788
http://dx.doi.org/10.1038/s41598-023-44548-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10576765/
https://www.ncbi.nlm.nih.gov/pubmed/37838788
http://dx.doi.org/10.1038/s41598-023-44548-y

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