EOGT enables residual Notch signaling in mouse intestinal cells lacking POFUT1

Notch signaling determines cell fates in mouse intestine. Notch receptors contain multiple epidermal growth factor-like (EGF) repeats modified by O-glycans that regulate Notch signaling. Conditional deletion of protein O-fucosyltransferase 1 (Pofut1) substantially reduces Notch signaling and markedl...

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Detalles Bibliográficos
Autores principales: Nauman, Mohd, Varshney, Shweta, Choi, Jiahn, Augenlicht, Leonard H., Stanley, Pamela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10576774/
https://www.ncbi.nlm.nih.gov/pubmed/37838775
http://dx.doi.org/10.1038/s41598-023-44509-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10576774/
https://www.ncbi.nlm.nih.gov/pubmed/37838775
http://dx.doi.org/10.1038/s41598-023-44509-5

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