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Automated imaging and identification of proteoforms directly from ovarian cancer tissue
The molecular identification of tissue proteoforms by top-down mass spectrometry (TDMS) is significantly limited by throughput and dynamic range. We introduce AutoPiMS, a single-ion MS based multiplexed workflow for top-down tandem MS (MS(2)) directly from tissue microenvironments in a semi-automate...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10576781/ https://www.ncbi.nlm.nih.gov/pubmed/37838706 http://dx.doi.org/10.1038/s41467-023-42208-3 |