Automated imaging and identification of proteoforms directly from ovarian cancer tissue

The molecular identification of tissue proteoforms by top-down mass spectrometry (TDMS) is significantly limited by throughput and dynamic range. We introduce AutoPiMS, a single-ion MS based multiplexed workflow for top-down tandem MS (MS(2)) directly from tissue microenvironments in a semi-automate...

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Detalles Bibliográficos
Autores principales: McGee, John P., Su, Pei, Durbin, Kenneth R., Hollas, Michael A. R., Bateman, Nicholas W., Maxwell, G. Larry, Conrads, Thomas P., Fellers, Ryan T., Melani, Rafael D., Camarillo, Jeannie M., Kafader, Jared O., Kelleher, Neil L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10576781/
https://www.ncbi.nlm.nih.gov/pubmed/37838706
http://dx.doi.org/10.1038/s41467-023-42208-3

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