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The physiological and pathological properties of Mead acid, an endogenous multifunctional n-9 polyunsaturated fatty acid

Mead acid (MA, 5,8,11-eicosatrienoic acid) is an n-9 polyunsaturated fatty acid (PUFA) and a marker of essential fatty acid deficiency, but nonetheless generally draws little attention. MA is distributed in various normal tissues and can be converted to several specific lipid mediators by lipoxygena...

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Autores principales: Kawashima, Hiroshi, Yoshizawa, Katsuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10576882/
https://www.ncbi.nlm.nih.gov/pubmed/37838679
http://dx.doi.org/10.1186/s12944-023-01937-6
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author Kawashima, Hiroshi
Yoshizawa, Katsuhiko
author_facet Kawashima, Hiroshi
Yoshizawa, Katsuhiko
author_sort Kawashima, Hiroshi
collection PubMed
description Mead acid (MA, 5,8,11-eicosatrienoic acid) is an n-9 polyunsaturated fatty acid (PUFA) and a marker of essential fatty acid deficiency, but nonetheless generally draws little attention. MA is distributed in various normal tissues and can be converted to several specific lipid mediators by lipoxygenase and cyclooxygenase. Recent pathological and epidemiological studies on MA raise the possibility of its effects on inflammation, cancer, dermatitis and cystic fibrosis, suggesting it is an endogenous multifunctional PUFA. This review summarizes the biosynthesis, presence, metabolism and physiological roles of MA and its relation to various diseases, as well as the significance of MA in PUFA metabolism.
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spelling pubmed-105768822023-10-16 The physiological and pathological properties of Mead acid, an endogenous multifunctional n-9 polyunsaturated fatty acid Kawashima, Hiroshi Yoshizawa, Katsuhiko Lipids Health Dis Review Mead acid (MA, 5,8,11-eicosatrienoic acid) is an n-9 polyunsaturated fatty acid (PUFA) and a marker of essential fatty acid deficiency, but nonetheless generally draws little attention. MA is distributed in various normal tissues and can be converted to several specific lipid mediators by lipoxygenase and cyclooxygenase. Recent pathological and epidemiological studies on MA raise the possibility of its effects on inflammation, cancer, dermatitis and cystic fibrosis, suggesting it is an endogenous multifunctional PUFA. This review summarizes the biosynthesis, presence, metabolism and physiological roles of MA and its relation to various diseases, as well as the significance of MA in PUFA metabolism. BioMed Central 2023-10-14 /pmc/articles/PMC10576882/ /pubmed/37838679 http://dx.doi.org/10.1186/s12944-023-01937-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Kawashima, Hiroshi
Yoshizawa, Katsuhiko
The physiological and pathological properties of Mead acid, an endogenous multifunctional n-9 polyunsaturated fatty acid
title The physiological and pathological properties of Mead acid, an endogenous multifunctional n-9 polyunsaturated fatty acid
title_full The physiological and pathological properties of Mead acid, an endogenous multifunctional n-9 polyunsaturated fatty acid
title_fullStr The physiological and pathological properties of Mead acid, an endogenous multifunctional n-9 polyunsaturated fatty acid
title_full_unstemmed The physiological and pathological properties of Mead acid, an endogenous multifunctional n-9 polyunsaturated fatty acid
title_short The physiological and pathological properties of Mead acid, an endogenous multifunctional n-9 polyunsaturated fatty acid
title_sort physiological and pathological properties of mead acid, an endogenous multifunctional n-9 polyunsaturated fatty acid
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10576882/
https://www.ncbi.nlm.nih.gov/pubmed/37838679
http://dx.doi.org/10.1186/s12944-023-01937-6
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