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The physiological and pathological properties of Mead acid, an endogenous multifunctional n-9 polyunsaturated fatty acid
Mead acid (MA, 5,8,11-eicosatrienoic acid) is an n-9 polyunsaturated fatty acid (PUFA) and a marker of essential fatty acid deficiency, but nonetheless generally draws little attention. MA is distributed in various normal tissues and can be converted to several specific lipid mediators by lipoxygena...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10576882/ https://www.ncbi.nlm.nih.gov/pubmed/37838679 http://dx.doi.org/10.1186/s12944-023-01937-6 |
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author | Kawashima, Hiroshi Yoshizawa, Katsuhiko |
author_facet | Kawashima, Hiroshi Yoshizawa, Katsuhiko |
author_sort | Kawashima, Hiroshi |
collection | PubMed |
description | Mead acid (MA, 5,8,11-eicosatrienoic acid) is an n-9 polyunsaturated fatty acid (PUFA) and a marker of essential fatty acid deficiency, but nonetheless generally draws little attention. MA is distributed in various normal tissues and can be converted to several specific lipid mediators by lipoxygenase and cyclooxygenase. Recent pathological and epidemiological studies on MA raise the possibility of its effects on inflammation, cancer, dermatitis and cystic fibrosis, suggesting it is an endogenous multifunctional PUFA. This review summarizes the biosynthesis, presence, metabolism and physiological roles of MA and its relation to various diseases, as well as the significance of MA in PUFA metabolism. |
format | Online Article Text |
id | pubmed-10576882 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-105768822023-10-16 The physiological and pathological properties of Mead acid, an endogenous multifunctional n-9 polyunsaturated fatty acid Kawashima, Hiroshi Yoshizawa, Katsuhiko Lipids Health Dis Review Mead acid (MA, 5,8,11-eicosatrienoic acid) is an n-9 polyunsaturated fatty acid (PUFA) and a marker of essential fatty acid deficiency, but nonetheless generally draws little attention. MA is distributed in various normal tissues and can be converted to several specific lipid mediators by lipoxygenase and cyclooxygenase. Recent pathological and epidemiological studies on MA raise the possibility of its effects on inflammation, cancer, dermatitis and cystic fibrosis, suggesting it is an endogenous multifunctional PUFA. This review summarizes the biosynthesis, presence, metabolism and physiological roles of MA and its relation to various diseases, as well as the significance of MA in PUFA metabolism. BioMed Central 2023-10-14 /pmc/articles/PMC10576882/ /pubmed/37838679 http://dx.doi.org/10.1186/s12944-023-01937-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Kawashima, Hiroshi Yoshizawa, Katsuhiko The physiological and pathological properties of Mead acid, an endogenous multifunctional n-9 polyunsaturated fatty acid |
title | The physiological and pathological properties of Mead acid, an endogenous multifunctional n-9 polyunsaturated fatty acid |
title_full | The physiological and pathological properties of Mead acid, an endogenous multifunctional n-9 polyunsaturated fatty acid |
title_fullStr | The physiological and pathological properties of Mead acid, an endogenous multifunctional n-9 polyunsaturated fatty acid |
title_full_unstemmed | The physiological and pathological properties of Mead acid, an endogenous multifunctional n-9 polyunsaturated fatty acid |
title_short | The physiological and pathological properties of Mead acid, an endogenous multifunctional n-9 polyunsaturated fatty acid |
title_sort | physiological and pathological properties of mead acid, an endogenous multifunctional n-9 polyunsaturated fatty acid |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10576882/ https://www.ncbi.nlm.nih.gov/pubmed/37838679 http://dx.doi.org/10.1186/s12944-023-01937-6 |
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