A cyclic peptide-based PROTAC induces intracellular degradation of palmitoyltransferase and potently decreases PD-L1 expression in human cervical cancer cells

INTRODUCTION: Our previous research has found that degradation of palmitoyltransferase in tumor cells using a linear peptide PROTAC leads to a significant decrease in PD-L1 expression in tumors. However, this degradation is not a sustained and efficient process. Therefore, we designed a cyclic pepti...

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Detalles Bibliográficos
Autores principales: Shi, Yu-Ying, Dong, Di-Rong, Fan, Gang, Dai, Meng-Yuan, Liu, Miao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577221/
https://www.ncbi.nlm.nih.gov/pubmed/37849747
http://dx.doi.org/10.3389/fimmu.2023.1237964

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577221/
https://www.ncbi.nlm.nih.gov/pubmed/37849747
http://dx.doi.org/10.3389/fimmu.2023.1237964

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