Design, synthesis and biological evaluation of tetrahydroquinoxaline sulfonamide derivatives as colchicine binding site inhibitors

Colchicine binding site inhibitors (CBSIs) are potential microtubule targeting agents (MTAs), which can overcome multidrug resistance, improve aqueous solubility and reduce toxicity faced by most MTAs. Novel tetrahydroquinoxaline sulfonamide derivatives were designed, synthesized and evaluated for t...

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Detalles Bibliográficos
Autores principales: Dong, Haiyang, Lu, Lu, Song, Xueting, Li, Youkang, Zhou, Jinguang, Xu, Yungen, Zhang, Yahong, Qi, Jianguo, Liang, Tingting, Wang, Jianhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577396/
https://www.ncbi.nlm.nih.gov/pubmed/37849704
http://dx.doi.org/10.1039/d3ra05720h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577396/
https://www.ncbi.nlm.nih.gov/pubmed/37849704
http://dx.doi.org/10.1039/d3ra05720h

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