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Bloom syndrome patients and mice display accelerated epigenetic aging
Bloom syndrome (BSyn) is an autosomal recessive disorder caused by variants in the BLM gene, which is involved in genome stability. Patients with BSyn present with poor growth, sun sensitivity, mild immunodeficiency, diabetes, and increased risk of cancer, most commonly leukemias. Interestingly, pat...
Autores principales: | Lee, Jamie, Zhang, Joshua, Flanagan, Maeve, Martinez, Julian A., Cunniff, Christopher, Kucine, Nicole, Lu, Ake T., Haghani, Amin, Gordevičius, Juozas, Horvath, Steve, Chang, Vivian Y. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577546/ https://www.ncbi.nlm.nih.gov/pubmed/37594403 http://dx.doi.org/10.1111/acel.13964 |
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