Cargando…
A bifunctional kinase–phosphatase module balances mitotic checkpoint strength and kinetochore–microtubule attachment stability
Two major mechanisms safeguard genome stability during mitosis: the mitotic checkpoint delays mitosis until all chromosomes have attached to microtubules, and the kinetochore–microtubule error‐correction pathway keeps this attachment process free from errors. We demonstrate here that the optimal str...
Autores principales: | Corno, Andrea, Cordeiro, Marilia H, Allan, Lindsey A, Lim, Qian‐Wei, Harrington, Elena, Smith, Richard J, Saurin, Adrian T |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577578/ https://www.ncbi.nlm.nih.gov/pubmed/37712330 http://dx.doi.org/10.15252/embj.2022112630 |
Ejemplares similares
-
Kinetochore phosphatases suppress autonomous Polo-like kinase 1 activity to control the mitotic checkpoint
por: Cordeiro, Marilia H., et al.
Publicado: (2020) -
Cyclin B1 scaffolds MAD1 at the kinetochore corona to activate the mitotic checkpoint
por: Allan, Lindsey A, et al.
Publicado: (2020) -
Kinetochore–microtubule attachment is sufficient to satisfy the human spindle assembly checkpoint
por: Etemad, Banafsheh, et al.
Publicado: (2015) -
Mitotic checkpoints, MUGs and kinetochores
por: Brinkley, Bill R.
Publicado: (2013) -
The Role of Mitotic Kinases and the RZZ Complex in Kinetochore-Microtubule Attachments: Doing the Right Link
por: Barbosa, João, et al.
Publicado: (2022)