Secretion of mitochondrial DNA via exosomes promotes inflammation in Behçet's syndrome

Mitochondrial DNA (mtDNA) leakage into the cytoplasm can occur when cells are exposed to noxious stimuli. Specific sensors recognize cytoplasmic mtDNA to promote cytokine production. Cytoplasmic mtDNA can also be secreted extracellularly, leading to sterile inflammation. However, the mode of secreti...

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Detalles Bibliográficos
Autores principales: Konaka, Hachiro, Kato, Yasuhiro, Hirano, Toru, Tsujimoto, Kohei, Park, JeongHoon, Koba, Taro, Aoki, Wataru, Matsuzaki, Yusei, Taki, Masayasu, Koyama, Shohei, Itotagawa, Eri, Jo, Tatsunori, Hirayama, Takehiro, Kawai, Taro, Ishii, Ken J, Ueda, Mitsuyoshi, Yamaguchi, Shigehiro, Akira, Shizuo, Morita, Takayoshi, Maeda, Yuichi, Nishide, Masayuki, Nishida, Sumiyuki, Shima, Yoshihito, Narazaki, Masashi, Takamatsu, Hyota, Kumanogoh, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577637/
https://www.ncbi.nlm.nih.gov/pubmed/37661814
http://dx.doi.org/10.15252/embj.2022112573

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577637/
https://www.ncbi.nlm.nih.gov/pubmed/37661814
http://dx.doi.org/10.15252/embj.2022112573

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