Systematic in vivo candidate evaluation uncovers therapeutic targets for LMNA dilated cardiomyopathy and risk of Lamin A toxicity

BACKGROUND: Dilated cardiomyopathy (DCM) is a severe, non-ischemic heart disease which ultimately results in heart failure (HF). Decades of research on DCM have revealed diverse aetiologies. Among them, familial DCM is the major form of DCM, with pathogenic variants in LMNA being the second most com...

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Detalles Bibliográficos
Autores principales: Tan, Chia Yee, Chan, Pui Shi, Tan, Hansen, Tan, Sung Wei, Lee, Chang Jie Mick, Wang, Jiong-Wei, Ye, Shu, Werner, Hendrikje, Loh, Ying Jie, Lee, Yin Loon, Ackers-Johnson, Matthew, Foo, Roger S. Y., Jiang, Jianming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577912/
https://www.ncbi.nlm.nih.gov/pubmed/37840136
http://dx.doi.org/10.1186/s12967-023-04542-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577912/
https://www.ncbi.nlm.nih.gov/pubmed/37840136
http://dx.doi.org/10.1186/s12967-023-04542-4

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