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Semi-rational engineering an aldo–keto reductase for stereocomplementary reduction of α-keto amide compounds
Enantio-pure α-hydroxy amides are valuable intermediates for the synthesis of chiral pharmaceuticals. The asymmetric reduction of α-keto amides to generate chiral α-hydroxy amides is a difficult and challenging task in biocatalysis. In this study, iolS, an aldo–keto reductase from Bacillus subtilis...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577934/ https://www.ncbi.nlm.nih.gov/pubmed/37840127 http://dx.doi.org/10.1186/s12934-023-02225-9 |