Vitamin C activates young LINE-1 elements in mouse embryonic stem cells via H3K9me3 demethylation

BACKGROUND: Vitamin C (vitC) enhances the activity of 2-oxoglutarate-dependent dioxygenases, including TET enzymes, which catalyse DNA demethylation, and Jumonji-domain histone demethylases. The epigenetic remodelling promoted by vitC improves the efficiency of induced pluripotent stem cell derivati...

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Detalles Bibliográficos
Autores principales: Cheng, Kevin C. L., Frost, Jennifer M., Sánchez-Luque, Francisco J., García-Canãdas, Marta, Taylor, Darren, Yang, Wan R., Irayanar, Branavy, Sampath, Swetha, Patani, Hemalvi, Agger, Karl, Helin, Kristian, Ficz, Gabriella, Burns, Kathleen H., Ewing, Adam, García-Pérez, José L., Branco, Miguel R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578016/
https://www.ncbi.nlm.nih.gov/pubmed/37845773
http://dx.doi.org/10.1186/s13072-023-00514-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578016/
https://www.ncbi.nlm.nih.gov/pubmed/37845773
http://dx.doi.org/10.1186/s13072-023-00514-6

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