A novel highly selective allosteric inhibitor of tyrosine kinase 2 (TYK2) can block inflammation- and autoimmune-related pathways

BACKGROUND: As a member of the Janus kinase (JAK) family, which includes JAK1, JAK2 and JAK3, tyrosine kinase 2 (TYK2) plays an important role in signal transduction and immune system regulation. Moreover, it is also involved in the development of many types of inflammatory and autoimmune diseases,...

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Detalles Bibliográficos
Autores principales: Chen, Celia X.-J., Zhang, Wei, Qu, Shulan, Xia, Fucan, Zhu, Yidong, Chen, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578023/
https://www.ncbi.nlm.nih.gov/pubmed/37845748
http://dx.doi.org/10.1186/s12964-023-01299-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578023/
https://www.ncbi.nlm.nih.gov/pubmed/37845748
http://dx.doi.org/10.1186/s12964-023-01299-7

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