Cargando…

A novel highly selective allosteric inhibitor of tyrosine kinase 2 (TYK2) can block inflammation- and autoimmune-related pathways

BACKGROUND: As a member of the Janus kinase (JAK) family, which includes JAK1, JAK2 and JAK3, tyrosine kinase 2 (TYK2) plays an important role in signal transduction and immune system regulation. Moreover, it is also involved in the development of many types of inflammatory and autoimmune diseases,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Celia X.-J., Zhang, Wei, Qu, Shulan, Xia, Fucan, Zhu, Yidong, Chen, Bo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578023/ https://www.ncbi.nlm.nih.gov/pubmed/37845748 http://dx.doi.org/10.1186/s12964-023-01299-7

Ejemplares similares

Novel Small Molecule Tyrosine Kinase 2 Pseudokinase Ligands Block Cytokine-Induced TYK2-Mediated Signaling Pathways
por: Zhou, Yu, et al.
Publicado: (2022)

Triple-action inhibitory mechanism of allosteric TYK2-specific inhibitors
por: Wang, Jimin, et al.
Publicado: (2023)

In vivo tumor surveillance by NK cells requires TYK2 but not TYK2 kinase activity
por: Prchal-Murphy, Michaela, et al.
Publicado: (2015)

TYK2: An Upstream Kinase of STATs in Cancer
por: Wöss, Katharina, et al.
Publicado: (2019)

Oncogenic TYK2 P760L kinase is effectively targeted by combinatorial TYK2, mTOR and CDK4/6 kinase blockade
por: Woess, Katharina, et al.
Publicado: (2022)

Identification of Gene-Tyrosine Kinase 2 (TYK2) in Head and Neck Squamous Cell Carcinoma Patients—An Integrated Bioinformatics Approach
por: Gong, Xiaoyan, et al.
Publicado: (2022)

Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL- 12
Publicado: (1995)

TYK2 in Tumor Immunosurveillance
por: Karjalainen, Anzhelika, et al.
Publicado: (2020)

Retracted: Identification of Gene-Tyrosine Kinase 2 (TYK2) in Head and Neck Squamous Cell Carcinoma Patients—An Integrated Bioinformatics Approach
por: Markers, Disease
Publicado: (2023)

Two common disease-associated TYK2 variants impact exon splicing and TYK2 dosage
por: Li, Zhi, et al.
Publicado: (2020)

Transcriptome analysis reveals a major impact of JAK protein tyrosine kinase 2 (Tyk2) on the expression of interferon-responsive and metabolic genes
por: Vogl, Claus, et al.
Publicado: (2010)

A comparative proteome analysis links tyrosine kinase 2 (Tyk2) to the regulation of cellular glucose and lipid metabolism in response to poly(I:C)
por: Grunert, Tom, et al.
Publicado: (2011)

Subtyping of Type 1 Diabetes as Classified by Anti-GAD Antibody, IgE Levels, and Tyrosine kinase 2 (TYK2) Promoter Variant in the Japanese
por: Mine, Keiichiro, et al.
Publicado: (2017)

A TYK2 Gene Mutation c.2395G>A Leads to TYK2 Deficiency: A Case Report and Literature Review
por: Wu, Peilin, et al.
Publicado: (2020)

TYK2 Kinase Activity Is Required for Functional Type I Interferon Responses In Vivo
por: Prchal-Murphy, Michaela, et al.
Publicado: (2012)

TYK2 in Immune Responses and Treatment of Psoriasis
por: Shang, Lin, et al.
Publicado: (2022)

Mendelian randomization and clinical trial evidence supports TYK2 inhibition as a therapeutic target for autoimmune diseases
por: Yuan, Shuai, et al.
Publicado: (2023)

Association of TYK2 polymorphisms with autoimmune diseases: A comprehensive and updated systematic review with meta-analysis
por: Pellenz, Felipe Mateus, et al.
Publicado: (2021)

TYK2 Promoter Variant and Diabetes Mellitus in the Japanese
por: Nagafuchi, Seiho, et al.
Publicado: (2015)

TYK2 Variants in B-Acute Lymphoblastic Leukaemia
por: Turrubiartes-Martínez, Edgar, et al.
Publicado: (2020)

TYK2 in Cancer Metastases: Genomic and Proteomic Discovery
por: Borcherding, Dana C., et al.
Publicado: (2021)

Tyk2 is a tumor suppressor in colorectal cancer
por: Moritsch, Stefan, et al.
Publicado: (2022)

Tyk2 Targeting in Immune-Mediated Inflammatory Diseases
por: Rusiñol, Lluís, et al.
Publicado: (2023)

TYK2 Protein-Coding Variants Protect against Rheumatoid Arthritis and Autoimmunity, with No Evidence of Major Pleiotropic Effects on Non-Autoimmune Complex Traits
por: Diogo, Dorothée, et al.
Publicado: (2015)

Structural basis of IFNα receptor recognition by TYK2
por: Wallweber, Heidi J.A., et al.
Publicado: (2014)

Functional characterization of NPM1–TYK2 fusion oncogene
por: Kuravi, Sudhakiranmayi, et al.
Publicado: (2022)

Prognostic values and clinical relationship of TYK2 in laryngeal squamous cell cancer
por: Fang, Lucheng, et al.
Publicado: (2021)

Allosteric Communication across the Native and Mutated KIT Receptor Tyrosine Kinase
por: Laine, Elodie, et al.
Publicado: (2012)

SIAH2 antagonizes TYK2-STAT3 signaling in lung carcinoma cells
por: Müller, Sylvia, et al.
Publicado: (2014)

A Novel Putative Role of TNK1 in Atherosclerotic Inflammation Implicating the Tyk2/STAT1 Pathway
por: Bao, Mei-Hua, et al.
Publicado: (2020)

The TYK2-P1104A Autoimmune Protective Variant Limits Coordinate Signals Required to Generate Specialized T Cell Subsets
por: Gorman, Jacquelyn A., et al.
Publicado: (2019)

Diabetes, the TYK2 Gene and the Interferon Response: In Search for Environmental Causes
por: Toniolo, Antonio, et al.
Publicado: (2017)

HSP90 inhibition leads to degradation of the TYK2 kinase and apoptotic cell death in T-cell acute lymphoblastic leukemia
por: Akahane, Koshi, et al.
Publicado: (2015)

Design, Synthesis and Activity Study of Pyridine Derivatives as Highly Effective and Selective TYK2 Inhibitors
por: Cheng, Chaoying, et al.
Publicado: (2022)

First‐in‐human study of deucravacitinib: A selective, potent, allosteric small‐molecule inhibitor of tyrosine kinase 2
por: Catlett, Ian M., et al.
Publicado: (2022)

Tyrosine Kinases in Autoimmune and Inflammatory Skin Diseases
por: Szilveszter, Kata P., et al.
Publicado: (2019)

Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases
por: Chen, Huaibin, et al.
Publicado: (2017)

Role of Tyk-2 in Th9 and Th17 cells in allergic asthma
por: Übel, Caroline, et al.
Publicado: (2014)

Compound heterozygous TYK2 mutations underlie primary immunodeficiency with T-cell lymphopenia
por: Nemoto, Michiko, et al.
Publicado: (2018)

Expression analysis of IFNAR1 and TYK2 transcripts in COVID-19 patients
por: Akbari, Mohammadarian, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_1bkp1gikids8l5udkcjg19a03t