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Zero‐shot mutation effect prediction on protein stability and function using RoseTTAFold
Predicting the effects of mutations on protein function and stability is an outstanding challenge. Here, we assess the performance of a variant of RoseTTAFold jointly trained for sequence and structure recovery, RF(joint), for mutation effect prediction. Without any further training, we achieve comp...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley & Sons, Inc.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578109/ https://www.ncbi.nlm.nih.gov/pubmed/37695922 http://dx.doi.org/10.1002/pro.4780 |