Molecular, metabolic, and functional CD4 T cell paralysis in the lymph node impedes tumor control

CD4 T cells are central effectors of anti-cancer immunity and immunotherapy, yet the regulation of CD4 tumor-specific T (T(TS)) cells is unclear. We demonstrate that CD4 T(TS) cells are quickly primed and begin to divide following tumor initiation. However, unlike CD8 T(TS) cells or exhaustion progr...

Descripción completa

Detalles Bibliográficos
Autores principales: Guo, Mengdi, Abd-Rabbo, Diala, Bertol, Bruna C., Carew, Madeleine, Lukhele, Sabelo, Snell, Laura M., Xu, Wenxi, Boukhaled, Giselle M., Elsaesser, Heidi, Halaby, Marie Jo, Hirano, Naoto, McGaha, Tracy L., Brooks, David G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578141/
https://www.ncbi.nlm.nih.gov/pubmed/37651234
http://dx.doi.org/10.1016/j.celrep.2023.113047

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578141/
https://www.ncbi.nlm.nih.gov/pubmed/37651234
http://dx.doi.org/10.1016/j.celrep.2023.113047

Ejemplares similares