Molecular, metabolic, and functional CD4 T cell paralysis in the lymph node impedes tumor control

CD4 T cells are central effectors of anti-cancer immunity and immunotherapy, yet the regulation of CD4 tumor-specific T (T(TS)) cells is unclear. We demonstrate that CD4 T(TS) cells are quickly primed and begin to divide following tumor initiation. However, unlike CD8 T(TS) cells or exhaustion progr...

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Detalles Bibliográficos
Autores principales: Guo, Mengdi, Abd-Rabbo, Diala, Bertol, Bruna C., Carew, Madeleine, Lukhele, Sabelo, Snell, Laura M., Xu, Wenxi, Boukhaled, Giselle M., Elsaesser, Heidi, Halaby, Marie Jo, Hirano, Naoto, McGaha, Tracy L., Brooks, David G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578141/
https://www.ncbi.nlm.nih.gov/pubmed/37651234
http://dx.doi.org/10.1016/j.celrep.2023.113047

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