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Targeting hypoxia-inducible factor-1 alpha suppresses Helicobacter pylori-induced gastric injury via attenuation of both cag-mediated microbial virulence and proinflammatory host responses

Helicobacter pylori-induced inflammation is the strongest known risk factor for gastric adenocarcinoma. Hypoxia-inducible factor-1 (HIF-1α) is a key transcriptional regulator of immunity and carcinogenesis. To examine the role of this mediator within the context of H. pylori-induced injury, we first...

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Detalles Bibliográficos
Autores principales: Noto, Jennifer M., Piazuelo, M. Blanca, Romero-Gallo, Judith, Delgado, Alberto G., Suarez, Giovanni, Akritidou, Konstantina, Girod Hoffman, Miguel, Roa, Juan Carlos, Taylor, Cormac T., Peek, Richard M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578190/
https://www.ncbi.nlm.nih.gov/pubmed/37828903
http://dx.doi.org/10.1080/19490976.2023.2263936