Cargando…

Targeting hypoxia-inducible factor-1 alpha suppresses Helicobacter pylori-induced gastric injury via attenuation of both cag-mediated microbial virulence and proinflammatory host responses

Helicobacter pylori-induced inflammation is the strongest known risk factor for gastric adenocarcinoma. Hypoxia-inducible factor-1 (HIF-1α) is a key transcriptional regulator of immunity and carcinogenesis. To examine the role of this mediator within the context of H. pylori-induced injury, we first...

Descripción completa

Detalles Bibliográficos
Autores principales:	Noto, Jennifer M., Piazuelo, M. Blanca, Romero-Gallo, Judith, Delgado, Alberto G., Suarez, Giovanni, Akritidou, Konstantina, Girod Hoffman, Miguel, Roa, Juan Carlos, Taylor, Cormac T., Peek, Richard M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2023
Materias:	Brief Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578190/ https://www.ncbi.nlm.nih.gov/pubmed/37828903 http://dx.doi.org/10.1080/19490976.2023.2263936

Ejemplares similares

Hydrogen Metabolism in Helicobacter pylori Plays a Role in Gastric Carcinogenesis through Facilitating CagA Translocation
por: Wang, Ge, et al.
Publicado: (2016)

Loss of TFF1 promotes Helicobacter pylori-induced β-catenin activation and gastric tumorigenesis
por: Soutto, Mohammed, et al.
Publicado: (2015)

Helicobacter pylori actively suppresses innate immune nucleic acid receptors
por: Dooyema, Samuel D.R., et al.
Publicado: (2022)

A review of signal pathway induced by virulent protein CagA of Helicobacter pylori
por: Wang, Haiqiang, et al.
Publicado: (2023)

The Host Protein Calprotectin Modulates the Helicobacter pylori cag Type IV Secretion System via Zinc Sequestration
por: Gaddy, Jennifer A., et al.
Publicado: (2014)

Modification of the Gastric Mucosal Microbiota by a Strain-Specific Helicobacter pylori Oncoprotein and Carcinogenic Histologic Phenotype
por: Noto, Jennifer M., et al.
Publicado: (2019)

Pathogenic Helicobacter pylori Strains Translocate DNA and Activate TLR9 via the Cancer-Associated cag Type IV Secretion System
por: Varga, Matthew G., et al.
Publicado: (2016)

Exosomes as nanocarriers for systemic delivery of the Helicobacter pylori virulence factor CagA
por: Shimoda, Asako, et al.
Publicado: (2016)

Genotyping of Helicobacter pylori Virulence Genes cagA and vacA: Regional and National Study
por: Kishk, Rania M., et al.
Publicado: (2021)

Mechanism of regulation of the Helicobacter pylori Cagβ ATPase by CagZ
por: Wu, Xiuling, et al.
Publicado: (2023)

Evolutionary History of the Helicobacter pylori Genome: Implications for Gastric Carcinogenesis
por: Correa, Pelayo, et al.
Publicado: (2012)

Regulation of p53 by Helicobacter pylori
por: Zaika, Alexander, et al.
Publicado: (2012)

Pan-genomic analyses identify key Helicobacter pylori pathogenic loci modified by carcinogenic host microenvironments
por: Noto, Jennifer M, et al.
Publicado: (2018)

Characterizing Helicobacter pylori cagA in Myanmar
por: Myint, Thein, et al.
Publicado: (2018)

Preservation of Helicobacter pylori CagA Translocation and Host Cell Proinflammatory Responses in the Face of CagL Hypervariability at Amino Acid Residues 58/59
por: Tafreshi, Mona, et al.
Publicado: (2015)

The Role of microRNAs in Helicobacter pylori Pathogenesis and Gastric Carcinogenesis
por: Noto, Jennifer M., et al.
Publicado: (2012)

Host immune response mediates changes in cagA copy number and virulence potential of Helicobacter pylori
por: Jang, Sungil, et al.
Publicado: (2022)

Helicobacter pylori Perturbs Iron Trafficking in the Epithelium to Grow on the Cell Surface
por: Tan, Shumin, et al.
Publicado: (2011)

Characterization of virulence genes cagA and vacA in Helicobacter Pylori and their prevalence in gastrointestinal disorders
por: Cogo, Laura Lúcia, et al.
Publicado: (2011)

Effects of the Helicobacter pylori Virulence Factor CagA and Ammonium Ion on Mucins in AGS Cells
por: Zhang, Xiaoyu, et al.
Publicado: (2018)

CagA(+) Helicobacter pylori, Not CagA(–) Helicobacter pylori, Infection Impairs Endothelial Function Through Exosomes-Mediated ROS Formation
por: Xia, Xiujuan, et al.
Publicado: (2022)

Temporal Control of the Helicobacter pylori Cag Type IV Secretion System in a Mongolian Gerbil Model of Gastric Carcinogenesis
por: Lin, Aung Soe, et al.
Publicado: (2020)

Helicobacter pylori CagA induced interleukin-8 secretion in gastric epithelial cells
por: Fazeli, Zeinab, et al.
Publicado: (2016)

Structure of the Helicobacter pylori Cag type IV secretion system
por: Chung, Jeong Min, et al.
Publicado: (2019)

Association between infection of virulence cagA gene Helicobacter pylori and laryngeal squamous cell carcinoma
por: Burduk, Paweł Krzysztof
Publicado: (2013)

Helicobacter pylori Virulence Factor Cytotoxin-Associated Gene A (CagA)-Mediated Gastric Pathogenicity
por: Ansari, Shamshul, et al.
Publicado: (2020)

Impact of Helicobacter pylori Infection and Its Major Virulence Factor CagA on DNA Damage Repair
por: Kontizas, Eleftherios, et al.
Publicado: (2020)

Helicobacter pylori with East Asian-type cagPAI genes is more virulent than strains with Western-type in some cagPAI genes
por: Yuan, Xiao-yan, et al.
Publicado: (2016)

Water-induced modulation of Helicobacter pylori virulence properties
por: Guimarães, Nuno M, et al.
Publicado: (2014)

Transgenic Expression of the Helicobacter pylori Virulence Factor CagA Promotes Apoptosis or Tumorigenesis through JNK Activation in Drosophila
por: Wandler, Anica M., et al.
Publicado: (2012)

Iron deficiency linked to altered bile acid metabolism promotes Helicobacter pylori–induced inflammation–driven gastric carcinogenesis
por: Noto, Jennifer M., et al.
Publicado: (2022)

The gastric microbiome, its interaction with Helicobacter pylori, and its potential role in the progression to stomach cancer
por: Noto, Jennifer M., et al.
Publicado: (2017)

Evolution of cagA Oncogene of Helicobacter pylori through Recombination
por: Furuta, Yoshikazu, et al.
Publicado: (2011)

Conformational Analysis of Isolated Domains of Helicobacter pylori CagA
por: Woon, Amanda P., et al.
Publicado: (2013)

Inhibition of Helicobacter pylori CagA-Induced Pathogenesis by Methylantcinate B from Antrodia camphorata
por: Lin, Chun-Jung, et al.
Publicado: (2013)

Helicobacter pylori virulence factor CagA promotes tumorigenesis of gastric cancer via multiple signaling pathways
por: Yong, Xin, et al.
Publicado: (2015)

Helicobacter pylori cagA gene variants in Malaysians of different ethnicity
por: Mohamed, Ramelah, et al.
Publicado: (2009)

Helicobacter Pylori Virulence Factor Cytotoxin-Associated Gene A (CagA) Induces Vascular Calcification in Coronary Artery Smooth Muscle Cells
por: Sundqvist, Martin O., et al.
Publicado: (2023)

CagI Is an Essential Component of the Helicobacter pylori Cag Type IV Secretion System and Forms a Complex with CagL
por: Pham, Kieu Thuy, et al.
Publicado: (2012)

Serum VEGF Levels in Helicobacter pylori Infection and Correlation with Helicobacter pylori cagA and vacA Genes
por: Siregar, Gontar, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_c9eemisg64aam88sou0jl0fl2g